Speakers:  Petter Brodin, Associate Professor of immunology at Karolinska Institutet & Yueh-hsiu Chien, Professor in the Department of Microbiology and Immunology at Stanford University

Original Broadcast date:  August 22 2018

Immune systems reflect the common challenges of existing in a potentially hostile external environment, and often exhibit a complex, ever-changing interplay between specialized cell types, potent effector molecules, and exogenously acquired molecules and organisms. Two major limitations of human immune system studies are their reliance on relatively few targeted assays and their potentially limited diversity within the samples examined. A systems biology approach maybe required to examine large numbers of different cell types and their interplay with real-time effector biomolecules, preferably using diverse sample cohorts. This webinar focuses on two such breakthrough studies (published in the journals Cell and Nature, respectively), which employ a broad, systems biology approach to better understand early postnatal immune system development, and the immunological control of latent infections.

The webinar covers the following points:

• How combining approaches such as mass cytometry, protein biomarker discovery, and transcriptomics provides valuable insights into complex immunological systems
• How the immune system develops in newborn children, and the external factors that influence this process
• New insights into the complex pathophysiology of latent infections with Mycobacterium tuberculosis, using a multi-omic, multicohort approach.

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