Download the PDF: 'Therapeutic Targets for Heart Failure Identified With Plasma Proteome and Genome Analysis'

In the following meta-analysis, eight proteins that may serve as therapeutic targets for heart failure were identified utilizing population-based proteomic studies, genomic data, and mendelian randomization. The study is a prime example of how such methods can enable faster discovery of drug targets in not only heart failure, but other diseases using proteomics and genomic data.

Article highlights

• Understand how proteogenomics can uncover robust therapeutic drug targets for heart failure.
• Learn more about mendelian randomization, and why it can be used to accurately inform the causal relationship between a protein, and disease
• Find out which of the eight identified proteins are rated for druggability and may serve as drug candidates for future drug development