What can the circulating proteome reveal about shared and distinct biology across neuropsychiatric conditions?

This White Paper explores large-scale UK Biobank proteomic data (generated through the Olink Explore research platform) across neurodegenerative, neurological, psychiatric, and addiction-related conditions to uncover both shared and disease-specific patterns. By integrating cross-disease protein associations with pathway-level analysis, it provides new insights into neuropsychiatric disease biology and highlights potential avenues for biomarker research and downstream validation.

What you'll learn:

• How the breadth, strength, and direction of proteomic associations differ across neuropsychiatric conditions

• Which protein signals recur across diseases, and which appear more disease-specific

• How cross-disease analysis reveals that the same protein can show different association directions across disorders

• How pathway enrichment adds biological context to individual protein associations

• How these complementary insights can support hypothesis generation, candidate prioritization, and downstream validation