Olink to Science

The accuracy of Olink Explore 1536 hits the nail on the head

Mar 15, 2021 9:30:00 AM / by Olink posted in Technical studies, Olink technology

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In our quest to realize the goal of precision medicine, it is crucial to develop accurate and precise proteomics platforms to measure biological variation in disease response in human populations. Antibody-based assay platforms allow the simultaneous measurement of multiple proteins, paving the way for proteomics analyses that result in meaningful insights into disease biology.

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Using Olink PEA technology and RNA-Seq to study disease pathology

Feb 22, 2021 9:30:00 AM / by Olink posted in Dermatological diseases, Inflammatory diseases, Technical studies, Multiomics, Clinical research, Interstitial fluid

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The following study illustrates how transcriptomics and proteomics complement one another to clarify the pathology of a complex, and little understood disease. Atopic dermatitis (AD) is the most common chronic skin condition affecting up to 20% of children and 7-10% of adults, depending on the population. The disease is incredibly complex and heterogenous, so finding an effective treatment has proven to be quite difficult. Moreover, the use of the skin biopsy as a method of sample collection is incredibly invasive and can cause scarring. Therefore, Rojahn et al. (2020) sought to test a less invasive and painful method known as skin blistering, which, unlike skin biopsies, would allow both transcriptomic analysis from skin cells, and proteomic analysis of the interstitial fluid from the blister.

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