To wrap up this month’s theme of Olink Explore 1536, here is an example of Olink Explore in action: To better understand the pathology of severe COVID-19 and why SARS-Co-V2 elicits a severe response in some patients, but not in others.

Advances in genomics have opened the doors to large-scale, high-throughput acquisition of biological data. As a result, our understanding of biology has increased substantially, so much so that this phase in history has been termed the 'DNA revolution'. But what about the workhorses of the body? What more could our proteome reveal? Just as genomics underwent a revolution, proteomics is having its own revolution right now. Introducing Olink Explore 1536, a product created for the screening and discovery of novel protein biomarkers.

To achieve the goal of precision medicine, not only do different molecular profiles need to be understood in disease populations, but they must also be understood in the context of healthy populations. This especially applies to the stability of molecular profiles among healthy individuals over time, as this will clarify what qualifies as a ‘normal range’ of clinical parameters in health and disease research. The following study by Tebani et al. (2020) conducted a longitudinal analysis of the blood profiles from 100 healthy individuals to understand how they varied both between different individuals, and within an individual over time.