Olink to Science

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Olink protein biomarker panel indicates fermented foods fight inflammation

Mar 29, 2021 9:30:00 AM / by Olink posted in Inflammatory diseases, Nutritional science, Proteomics

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How Olink Explore has been used to understand the pathology of severe COVID-19

Mar 22, 2021 9:30:00 AM / by Olink posted in Immunological diseases/Immunology, Respiratory disease, Plasma, Clinical research, Publications

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To wrap up this month’s theme of Olink Explore 1536, here is an example of Olink Explore in action: To better understand the pathology of severe COVID-19 and why SARS-Co-V2 elicits a severe response in some patients, but not in others.

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The accuracy of Olink Explore 1536 hits the nail on the head

Mar 15, 2021 9:30:00 AM / by Olink posted in Technical studies, Olink technology

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In our quest to realize the goal of precision medicine, it is crucial to develop accurate and precise proteomics platforms to measure biological variation in disease response in human populations. Antibody-based assay platforms allow the simultaneous measurement of multiple proteins, paving the way for proteomics analyses that result in meaningful insights into disease biology.

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Proteins in the Olink Explore 1536 library

Mar 8, 2021 9:30:00 AM / by Olink posted in Proteomics, Olink technology

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Olink Explore 1536 includes both the proteins you love and the proteins you wished to have. While Olink Explore features many established key protein assays from our other Olink products, we wanted Olink Explore to include novel protein biomarkers from the fast-progressing proteomics research field. This post describes the Olink Explore protein library, as well as highlights a couple of exciting new protein assays.

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Olink Explore 1536 measures over 1500 proteins

Mar 1, 2021 9:30:00 AM / by Olink posted in Wider proteomics studies, Plasma, Biomarkers, Multiomics, Basic research, Precision medicine, Olink technology

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Advances in genomics have opened the doors to large-scale, high-throughput acquisition of biological data. As a result, our understanding of biology has increased substantially, so much so that this phase in history has been termed the 'DNA revolution'. But what about the workhorses of the body? What more could our proteome reveal? Just as genomics underwent a revolution, proteomics is having its own revolution right now. Introducing Olink Explore 1536, a product created for the screening and discovery of novel protein biomarkers.

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Using Olink PEA technology and RNA-Seq to study disease pathology

Feb 22, 2021 9:30:00 AM / by Olink posted in Dermatological diseases, Inflammatory diseases, Technical studies, Multiomics, Clinical research, Interstitial fluid

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The following study illustrates how transcriptomics and proteomics complement one another to clarify the pathology of a complex, and little understood disease. Atopic dermatitis (AD) is the most common chronic skin condition affecting up to 20% of children and 7-10% of adults, depending on the population. The disease is incredibly complex and heterogenous, so finding an effective treatment has proven to be quite difficult. Moreover, the use of the skin biopsy as a method of sample collection is incredibly invasive and can cause scarring. Therefore, Rojahn et al. (2020) sought to test a less invasive and painful method known as skin blistering, which, unlike skin biopsies, would allow both transcriptomic analysis from skin cells, and proteomic analysis of the interstitial fluid from the blister.

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How the proteome behaves in healthy individuals

Feb 15, 2021 9:30:00 AM / by Olink posted in Wellness, Plasma, Multiomics, Clinical research, Precision medicine, Longitudinal Data

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To achieve the goal of precision medicine, not only do different molecular profiles need to be understood in disease populations, but they must also be understood in the context of healthy populations. This especially applies to the stability of molecular profiles among healthy individuals over time, as this will clarify what qualifies as a ‘normal range’ of clinical parameters in health and disease research. The following study by Tebani et al. (2020) conducted a longitudinal analysis of the blood profiles from 100 healthy individuals to understand how they varied both between different individuals, and within an individual over time.

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Protein biomarkers are crucial in early detection of cancer

Feb 8, 2021 9:30:00 AM / by Olink posted in Oncology, Wellness, Plasma, Biomarkers, Clinical research

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Key proteomics publications from 2020

Feb 1, 2021 10:56:17 AM / by Olink posted in Proteomics, Publications

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Welcome to the first post of the all-new weekly Olink to Science! Our customer survey revealed that you would like to know more about the many publications, research, and other science happening at Olink, therefore this blog aims to do just that: keep you informed on the exciting science taking place with our technology.

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